Roles of the WHHL Rabbit in Translational Research on Hypercholesterolemia and Cardiovascular Diseases

Table 2

Drug development using WHHL/WHHLMI rabbits.

	Lipid-lowering effect	Lipid-lowering effect
		Aorta	Coronary arteries
Cholesterol synthesis inhibitors
Statins	O	X, O	O
Squalene synthesis inhibitor	O	O	O
Anion exchanger	O	O
Statins + Anion exchanger	O	O	O
MTP inhibitor	O
ACAT inhibitor	X, O	X, O	X, O
Antioxidants
Probucol	O	O
Vitamin E	X	X, O
Colony stimulating factor
MCSF	X, O	O
GMCSF	X, O	O
Apo E	X, O	O
Fibrate	X
Fish oils, ommega-3 fatty acids	X, O	X, O
Thiazolidinedione	X	Δ	Δ
Thiazolidinedione + statin	O	O	O
Antihypertensive
ACE inhibitor	X	O
AT-II receptor antagonists	X	O
Calcium antagonists	X	X
Beta-blockers	X	X
Gene therapy	O

O: effective; Δ: partly effective; X: no effect.
Modified from Shiomi and Ito [8].