Research Article
Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans
Table 2
Relationships between UCP I/(I + III) ratio and each ABCC2 polymorphism using the Mann-Whitney test.
| | Polymorphism | Genotype | Frequency no. (%) | Median [interquartile range] UCP I/(I + III) ratio (%) | P value* |
| | ABCC2 −24 C/T | CC | 46 (62.2) |
26.9 [8.4] | .08 | | CT | 25 (33.8) | | TT | 3 (4.0) | 33.8 [5.8] |
| | ABCC2 1249 G/A | GG | 52 (70.2) |
27.8 [8.4] | .39 | | GA | 21 (28.4) | | AA | 1 (1.4) | 33.6 [na] |
| | ABCC2 3563 T/A | TT | 64 (86.5) |
28 [8.6] | — | | TA | 10 (13.5) | | AA | 0 | — |
| | ABCC2 3972 C/T | CC | 29 (37.7) |
26.7 [7.6] | .04 | | CT | 37 (49.3) | | TT | 8 (12.0) | 33.1 [3.1] |
| | ABCC2 4544 G/A | GG | 64 (86.5) |
28 [8.6] | — | | GA | 10 (13.5) | | AA | 0 | — |
|
|
*Wild-type allele carriers versus homozygous variant.
|
