Chromosomal Rearrangements in Post-Chernobyl Papillary Thyroid Carcinomas: Evaluation by Spectral Karyotyping and Automated Interphase FISH
Figure 2
FISH analysis of RET/PTC rearrangement: S414N nontumour cells showing two fused red and green signals; S422T tumour cells have one fused and one split red/green signal pair, indicating a RET gene rearrangement. Cells were hybridized with YAC probes 313F4 and 214H10 (FITC labelled, green signals) and 344H4 (Cy3 labeled, red signals). Arrows indicate the split signals of RET/PTC rearrangements.
