Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development
Figure 2
Diagrams and equations for a perfusion rate-limited, one-compartment model (a) and a permeability rate-limited, two-compartment model with the permeability at the vascular membrane (b) of noneliminating organs, adapted from Nestorov et al. [15]. Q = blood flow; C = concentration; V = volume; Kp = tissue : plasma distribution coefficient; PS = permeability surface area coefficient; subscripts T, ART, VEN, V, and EV indicate tissue, arterial, venous, vascular compartment, and extravascular compartment, respectively.
