Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development
Figure 6
Predicted dose-normalized pediatric plasma concentration-time curves (lines) versus observed data (symbols) for (a) alfentanil and (b) morphine as reported in the original study by Edginton et al. [52]. Observed data was obtained from various studies in the literature.
