Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

<table>Schematic drawing of a potential application of PBPK simulations for children of different ages to find optimal blood sampling time points for the pharmacokinetic investigations in a future pediatric trial according to Willmann [<a href="/journals/bmri/2011/907461/#B58">54</a>]. Arrows indicate optimal sampling time for a 3-year-old child, a newborn, and an adult. LOQ: limit of quantification.</table>

BioMed Research International

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Figure 8: Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development 

Figure 8 | Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development 