Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

Table 2

Values of organ blood flows, portal blood flow, total hepatic blood flow (QH), bodyweight, and height that were used in the PBPK model developed and reported by Edginton et al. [52].

Parameter	New born	1y	5 y	10 y	15 y	Adult (30 y)
Organ blood flow (mL/min)
Adipose	30	12	171	250	315/484^a	325/502^a
Brain	180	700	900	840/750^a	805/708^a	780/708^a
Gonads	0.3	0.6	1.7/0.7^a	2.5/1.0^a	3.2/1.1^a	3.3/1.2^a
Heart	24	48	136	200	252/285^a	260/295^a
Kidneys	110	230	577	854	1335/950^a	1325/1120^a
Large intestine	24	48	136	200	251/285^a	260/295^a
Liver	39	78	221	325	409/370^a	423/383^a
Muscle	31	72	212	429	941/646^a	1105/665^a
Pancreas	6	12	34	50	63/57^a	65/59^a
Skeleton	30	60	170	250	315/285^a	325/295^a
Skin	30	60	170	250	315/285^a	325/295^a
Small intestine	60	120	340	500	630/627^a	650/649^a
Spleen	18	36	102	150	189/171^a	195/177^a
Stomach	6	12	34	50	63/57^a	65/59^a
Portal blood flow (mL/min)	114	228	646	950/950^a	1197/1197^a	1235/1239^a
QH (mL/min)*	153	306	867	1275/1273^a	1600/1566^a	1660/1620^a
Body weight (kg)	3.5	10	19	32	56/53^a	73/60^a
Height (cm)	51	76	109	138	167/161^a	176/163^a

a = Male/female; *Q_H = total hepatic blood flow.