Effect of PGC-1α on Proliferation, Migration, and Transdifferentiation of Rat Vascular Smooth Muscle Cells Induced by High Glucose
Figure 4
Phagocytosis of VSMCs. VSMCs deprived of serum for 24 h were infected by Ad-PGC-1α or Ad-GFP. After 48 h, VSMCs were incubated with 1 μm microspheres (2.7 × 106 beads per mL) for 10 h. 27.36% of VSMCs infected by Ad-GFP had phagocytotic activity. However, the proportion of VSMCs having phagocytotic activity increased to 77.45% after overexpression of PGC-1α.
