CpG ODN and ISCOMATRIX Adjuvant: A Synergistic Adjuvant Combination Inducing Strong T-Cell IFN- Responses
Figure 7
BALB/c mice (/group) were immunized on days 0 and 28 by IM injection of 1 μg HBsAg either alone (none) or combined with CpG (10 μg), ISCOMATRIX (IMX) (1 μg), aluminum hydroxide (alum) (25 μg Al3+), CpG (10 μg) + aluminum hydroxide (alum) (25 μg Al3+), or CpG (10 μg) + ISCOMATRIX (1 μg). Spleens were removed 4 wks after the second immunization and IFN-γ secretion was measured by ELISA in antigen-restimulated splenocytes culture supernatants.
