Coefficient of Energy Balance: Effective Tool for Early Differential Diagnosis of CNS Diseases

Table 1

Reference ranges of selected parameters of basic CSF examination (determined at our laboratory) [3, 4, 17–21].

Parameter	Age	Range	Unit
Energy metabolism
𝑄glu		0.55–0.65	—
LactateCSF		0.7–2.1	mmol/L
Cytology
Number of leukocytes		0–4	/1 µL
Cytological composition	Lymphocyte : monocyte = 7 : 3
Permeability of blood-CSF barrier
Total proteinCSF (TPCSF)	0–2 weeks	450.0–1090.0	mg/L
	2–4 weeks	510.0–1010.0
	1–3 months	240.0–650.0
	3–6 months	230.0–370.0
	6–12 months	170.0–350.0
	1–10 years	160.0–310.0
	11–18 years	160.0–400.0
	19–40 years	240.0–490.0
	41–50 years	270.0–600.0
	51–60 years	290.0–670.0
	61–70 years	260.0–790.0
Albumin quotient (𝑄alb); 𝑄alb = [albuminCSF]/[albuminblood]	0–2 weeks	5.6–23.2	×10^𝐸−3
	2–4 weeks	7.6–16.4
	1–3 months	2.3–10.6
	3–6 months	2.0–4.8
	6–12 months	1.4–4.5
	1–10 years	1.0–4.5
	11–18 years	1.0–5.0
	19–30 years	1.7–5.7
	31–40 years	1.8–6.2
	41–50 years	2.0–7.2
	51–60 years	2.1–8.9
	61–70 years	2.2–9.9
Inflammatory activity
Beta-2-microglobulinCSF		0.2–2.0	mg/L
Intrathecal synthesis-IgG (Reiber)		0	%
Intrathecal synthesis-IgA (Reiber)		0	%
Intrathecal synthesis-IgM (Reiber)		0	%