Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: <i>In Vitro</i> and <i>In Vivo</i> Evaluation

<table>3D response surface plots showing effect of w/o phase ratio (<i>X </i><sub>3</sub>) and drug concentration (<i>X </i><sub>4</sub>) on % drug entrapment.</table>

BioMed Research International

fig5

Figure 5

Figure 5: Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: <i>In Vitro</i> and <i>In Vivo</i> Evaluation 

Figure 5 | Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation 