[Retracted] Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells

Table 2

Cytotoxicity of ADR alone and in combination with VER or CH in K562 and K562/ADR cells in vitro.

Drug and concentration	IC50 (M)		Resistance times	Reversing times
	K562	K562/ADR
ADR			31.04
ADR + CH; (5 μM)			3.68	8.43
ADR + VER; (5 μM)			13.19	2.35

Cells were exposed to various concentrations of ADR, with or without 5 M CH, or VER for 48 h. * compared with K562 treated with ADR, or ADR cotreated with CH or VER, ^△ compared with K562/ADR treated with ADR, ^☆ compared with K562/ADR treated with ADR plus CH.