Pathway-Driven Discovery of Rare Mutational Impact on Cancer

Table 1

Curated drug target centric pathways.

Target	Drugs	First neighbors
EGFR	cetuximab, AEE 788, panitumumab, BMS-599626, ARRY-334543, XL647, canertinib, gefitinib, HKI-272, PD 153035, lapatinib, vandetanib, erlotinib	125
PDGRFB	dasatinib, sunitinib, pazopanib, axitinib, KRN-951, tandutinib, imatinib, sorafenib, becaplermin	61
ERBB2	trastuzumab, BMS-599626, ARRY-334543, XL647, CP-724,714, HKI-272, lapatinib, erlotinib	59
MET	crizotinib	55
ERBB4	BMS-599626	44
KIT	dasatinib, sunitinib, pazopanib, KRN-951, OSI-930, telatinib, tandutinib, imatinib, sorafenib	38
FLT4	sunitinib, pazopanib, CEP 7055, KRN-951, telatinib, sorafenib, vandetanib	36
PDGFRA	sunitinib, pazopanib, axitinib, telatinib, imatinib, becaplermin	35
TEK	Vandetanib	35
RET	sunitinib, vandetanib	30
FGFR1	Pazopanib	29
EPHA2	Dasatinib	22
FGFR3	Pazopanib	18
FLT3	CHIR-258, tandutinib, sorafenib, lestaurtinib, CGP 41251	14
FGFR2	Palifermin	13