Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma
Figure 2
Systemic delivery of miR-34a SNALPs formulations inhibits growth of human MM tumors in mice. (a) Mice carrying palpable subcutaneous SKMM-1 tumor xenografts were treated with 20 μg of pre-miR-34a or miR-34a OMet SNALPs or Tf-SNALPs formulations by intravenous tail vein injections. Caliper measurement of tumors was taken every 2 days from the day of first treatment. Averaged tumor volumes of 5 mice per group are reported ± SD. (b) Survival curves (Kaplan-Meier) of treated mice show prolongation of survival after formulated miR-34a treatment compared to controls (log-rank test, ). Survival was evaluated from the first day of treatment until death or sacrifice.
