An Evaluation of 3-Rhamnosylquercetin, a Glycosylated Form of Quercetin, against the Myotoxic and Edematogenic Effects of sPLA2 from Crotalus durissus terrificus
Figure 5
(a) shows the results of paw edema that was induced after the injection of sPLA2, sPLA2 : Q, and sPLA2 : Qn into the right paws of Swiss mice. Measurements were made after 30, 60, 120, and 240 min, and all the edema results expressed in (a) were obtained by subtracting the saline injection values. (b) shows the myonecrosis levels as evaluated by CK levels in Swiss mice. Fifty micrograms of native sPLA2, sPLA2 : Q, and sPLA2 : Qn at a final concentration of 0.5 mg/mL were injected into the gastrocnemius muscle. The results are expressed as units of enzymatic activity per liter (U/L). Error bars indicate the SEM. * compared to native sPLA2.
