Yokukansan, a Traditional Japanese Medicine, Adjusts Glutamate Signaling in Cultured Keratinocytes
Figure 2
AD-like lesions produce and release glutamate in the skin of NCNga mice. The dermatitis scores of the conventional control mice were aggravated. YKS-treated mice significantly inhibited the aggravation of skin lesions in NCNga mice. (a) The glutamate concentrations in the skin of the NC/Nga mice, as determined by ELISA, were significantly increased in the conventional control mice compared with the SPF control mice. However, the glutamate concentrations were significantly decreased in the YKS-treated mice compared with the conventional control mice. (b) Measurements were compared between the SPF control and conventional control groups (conventional control: nontreated, YKS-treated). , , and .
