Notch1 and 4 Signaling Responds to an Increasing Vascular Wall Shear Stress in a Rat Model of Arteriovenous Malformations
Figure 5
Blood flow shear stress induces the interaction events between Notch receptor1 or 4 and their ligands in the “nidus” vessel wall 42 days after AVF formation. Green dots indicate interaction events: the interaction events between Notch receptor1 and its ligand Delta1 (a), Notch1 and Delta4 (b), Notch1 and Jagged1 (c), Notch receptor4 and Delta1 (d), Notch4 and Delta4 (e), and Notch4 and Jagged1 (f), respectively. In situ proximity ligation assay, original magnification ×10 for (a), and ((c)–(f)); ×63 for (b).
