Effects of Various Antibiotics Alone or in Combination with Doripenem against Klebsiella pneumoniae Strains Isolated in an Intensive Care Unit

Table 2

The PAE values for tested antibiotics.

Antibiotic	Bacteria	Special conditions	Duration of PAE (H)	Author/year	Reference number
Levofloxacin	K. pneumoniae	1 and 4x MIC	1.35 and 4.72	Present study
	K. pneumoniae	0.5x MIC	1.80	Spangler et al./2000	[24]
Colistin	K. pneumoniae	1 and 4x MIC	2.71 and 4.23	Present study
	A. baumannii	1 and 4x MIC	3.00 and 6.28	Özbek and Şentürk/2010	[25]
	P. aeruginosa	1 and 20x MIC	1.13 and 2.12	Bozkurt-Güzel and Gerçeker/2012	[26]
	P. aeruginosa	16x MIC	2.00 and 3.00	Li et al./2001	[27]
	A. baumannii ATCC 19606	16, 32 and 64x MIC	1.00, 2.30 and 3.50	Owen et al./2007	[28]
Tobramycin	K. pneumoniae	1 and 4x MIC	1.31 and 3.82	Present study
	P. aeruginosa	1 and 10x MIC	1.50 and 3.10	Ozbek and Otuk/2009	[29]
	P. aeruginosa	In vivo	2.00 to 4.00	Gudmundsson et al./1993	[30]
	Gram-negative bacteria	In vivo	3.00 to 4.00	Spivey/1992	[17]
Tigecycline	K. pneumoniae	1 and 4x MIC	1.18 and 1.55	Present study
	K. pneumoniae	2 and 10x MIC	1.70 and 1.80	Pankuch and Appelbaum/2009	[31]
	Enterococcus faecalis	1 to 20x MIC	1.00 and 4.50	Lefort et al./2003	[32]
Rifampin	K. pneumoniae	1 and 4x MIC	0.92 and 1.19	Present study
	E. coli ATCC 25922	5x MIC	4.00	Stubbings et al./2006	[33]
	Legionella pneumophila	4x MIC	2.86 and 3.09	Dubois and St-Pierre/2000	[34]
Doripenem	K. pneumoniae	1 and 4x MIC	0.10 and 0.18	Present study
	E. coli and P. aeruginosa	10x MIC	Weak or No PAE for meropenem	Odenholt-Tornqvist/1993	[35]