Detecting Epistatic Interactions in Metagenome-Wide Association Studies by metaBOOST

Procedure 1

Procedure for the permutation test.

Permutation test for metaBOOST

Calculate the likelihood ratio using original data, denoted as 𝑂𝑟𝑖𝑔𝑖𝑛𝑎𝑙.

for 𝑖=1∶𝑁

 Permute the disease-control label of samples.

 Calculate the likelihood ratio using permuted labels, denoted as 𝑃𝑒𝑟𝑚𝑢𝑡𝑒(𝑖).

end

Final 𝑃 value would be 𝑃_{𝑝𝑒𝑟𝑚𝑢𝑡𝑒𝑑}=#{𝑃𝑒𝑟𝑚𝑢𝑡𝑒>𝑂𝑟𝑖𝑔𝑖𝑛𝑎𝑙}𝑁.