Expression of Neuroendocrine Markers in Different Molecular Subtypes of Breast Carcinoma

Table 1

Expression of specific (chromogranin A and synaptophysin) and non-specific (CD56, CD117, NSE) neuroendocrine markers in different molecular subtypes of breast carcinoma, DCIS, and normal tissue.

Molecular subtype	Chromogranin A	Synaptophysin	CD56	CD117	NSE
Luminal A
Focal (<50%)	0/25 (0%)	1/24 (4.2%)	1/24 (4.2%)	0/22 (0%)	1/23 (4.3%)
Diffuse (>50%)	0/25 (0%)	0/24 (0%)	3/24 (12.5%)	1/22 (4.5%)	17/23 (73.9%)
Luminal B
Focal (<50%)	1/18 (5.6%)	3/18 (16.7%)	0/18 (0%)	1/18 (5.6%)	6/17 (35.3%)
Diffuse (>50%)	2/18 (11.1%)	3/18 (16.7%)	0/18 (0%)	1/18 (5.6%)	6/17 (35.3%)
HER2
Focal (<50%)	1/15 (6.7%)	2/15 (13.3%)	0/14 (0%)	0/15 (0%)	4/15 (26.7%)
Diffuse (>50%)	0/15 (0%)	0/15 (0%)	0/14 (0%)	2/15 (13.3%)	2/15 (13.3%)
Basal-like
Focal (<50%)	0/29 (0%)	1/29 (3.4%)	4/29 (13.8%)	0/29 (0%)	0/29 (0%)
Diffuse (>50%)	0/29 (0%)	0/29 (0%)	4/29 (13.8%)	12/29 (41.4%)	13/29 (44.8%)
High-grade DCIS
Focal (<50%)	1/10 (10%)	2/10 (20%)	1/10 (10%)	2/10 (20%)	3/10 (30%)
Diffuse (>50%)	0/10 (0%)	0/10 (0%)	0/10 (0%)	1/10 (10%)	3/10 (30%)
Low-grade DCIS
Focal (<50%)	0/6 (0%)	0/6 (0%)	0/7 (0%)	1/5 (20%)	1/5 (20%)
Diffuse (>50%)	0/6 (0%)	0/6 (0%)	0/7 (0%)	0/5 (0%)	4/5 (80%)
Normal tissue
Focal (<50%)	0/69 (0%)	5/69 (7.2%)	44/62 (70.9%)	10/67 (14.9%)	25/64 (39.1%)
Diffuse (>50%)	0/69 (0%)	0/69 (0%)	1/62 (1.6%)	55/67 (82.1%)	25/64 (39.1%)