Fibrinogen Alpha Chain Precursor and Apolipoprotein A-I in Urine as Biomarkers for Noninvasive Diagnosis of Calcium Oxalate Nephrolithiasis: A Proteomics Study
Table 1
General information of nephrolithiasis patients and healthy volunteers.
Characteristics
Training set
Test set
Total
Nephrolithiasis
Number of cases ()
54
18
72
Gender (M/F)
32/22
12/6
44/28
Mean age (years)
33.5 ± 4.9
30.4 ± 5.3
32.9 ± 5.0
Stone size (length × width × height/mm)
18 ± 6 × 10 ± 1.5 × 14 ± 6
11 ± 3 × 7 ± 1 × 10 ± 2a
15 ± 4 × 9 ± 1 × 12 ± 4
Grade of hydronephrosis
I
19
4
23
II
30
6
36
III
10
3
13
Blood urea nitrogen (mmol/L)
5.5 ± 1.2
4.9 ± 0.9a
5.2 ± 1.4
Serum creatinine (mol/L)
87.19 ± 7.98
79.41 ± 9.16a
84.74 ± 6.98
Volunteers
Number of cases ()
24
6
30
Gender (M/F)
17/7
4/2
21/9
Mean age (years)
25.6 ± 3.7
27.2 ± 1.8
26.1 ± 2.5
Blood urea nitrogen (mmol/L)
4.8 ± 0.4
4.2 ± 1.5b
4.5 ± 0.9
Serum creatinine (mol/L)
66.91 ± 5.49
62.43 ± 4.17b
64.89 ± 4.88
, test set compared with training set in nephrolithiasis , test set compared with training set in healthy volunteers. Standard BUN 1.8–7.1 mmol/L, standard SCr 59–104 mmol/L.
