Iron as the Key Modulator of Hepcidin Expression in Erythroid Antibody-Mediated Hypoplasia

Figure 6

Model proposed for erythropoiesis and iron metabolism in erythroid antibody-mediated hypoplasia. Anti-rHuEPO antibodies inhibit both rHuEPO and endogenous EPO leading to anemia that is further aggravated by increased iron that favours hepcidin expression.