Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma

Table 1

Expression of 𝛼-SMA and related molecules in nasopharyngeal tissues.

	Location		Group	IHC grade^#					𝑃 value*
	Stroma	Cancer nest		−	+	++	+++	++++
𝛼-SMA	Positive^$	ND	Chronic nasopharyngitis (21)	11	7	2	1	0	0.000
			NPC (18)	0	4	0	7	7
CD133	Positive	ND	Chronic nasopharyngitis (10)	9	1	0	0	0	0.006
			NPC (30)	8	9	9	4	0
VEGFR-2	Positive	ND	Chronic nasopharyngitis (8)	7	1	0	0	0	0.04
			NPC (10)	2	5	1	2	0
CD34	Positive	ND	Chronic nasopharyngitis (14)	0	8	6	0	0	0.000
			NPC (24)	0	0	3	7	14
CXCR4	Positive	Positive	Chronic nasopharyngitis (6)	0	3	1	2	0	0.041
			NPC (11)	0	0	2	4	5
VEGF-A	Positive	Positive	Chronic nasopharyngitis (10)	0	1	5	4	0	0.015
			NPC (19)	0	0	2	9	8
SDF-1	ND	Positive	Chronic nasopharyngitis (22)	5	9	5	2	1	0.008
			NPC (20)	3	0	7	5	5

#IHC grades were assigned to each specimen according to the grade of staining intensity as described in Section 2.
* 𝑃 values were calculated by the chi-square test in comparison to chronic nasopharyngitis tissues.
$IHC reactivity: positive; ND: not detected.