Therapeutic Potential of Tacrolimus on Acute Myocardial Infarction in Minipigs: Analysis with Serial Cardiac Magnetic Resonance and Changes at Histological and Protein Levels
Figure 4
Immunohistochemical staining with α-smooth muscle actin for quantification of the blood vessels in myocardium in the AMI area of the control (a), AMI area of the tac-treated (b), peri-AMI area of the control (c), peri-AMI area of the tac-treated (d), and normal groups (e). Note the significantly more small vessels (≤25 m) (arrows) in normal than in the controls and the tac-treated minipigs (∗ versus other groups, all ), and significantly reduced small vessels in the controls than in the tac-treated minipigs († versus ‡, versus , all ) (f). Scale bars in right lower corner represent 20 m.
