Research Article
Disease Activity in Psoriatic Arthritis: Comparison of the Discriminative Capacity and Construct Validity of Six Composite Indices in a Real World
Table 1
Demographic, clinical, and laboratory data of study population.
| | | Mean | SD | Median | 25–75 P |
| | Demographic data | | | | | | Age (yrs) | 51.55 | 11.61 | 51.00 | 42.50–59.00 | | Gender (M/F) | | | | | | Duration psoriatic arthritis (yrs) | 7.48 | 4.96 | 6.00 | 3.00–11.00 | | Duration of psoriasis (yrs) | 13.87 | 6.98 | 12.00 | 7.00–16.00 | | Acute phase reactants | | | | | | ESR (mm/h) | 27.50 | 28.48 | 22.00 | 13.00–34.00 | | CRP (m/dL) | 4.42 | 7.06 | 1.55 | 0.54–4.88 | | Enthesis/dactylitis counts | | | | | | Leeds Enthesitis Index (range 0–6) | 1.02 | 1.24 | 1.00 | 0.00–1.50 | | Dactylitis count (range 0–20) | 1.04 | 1.07 | 1.00 | 0.00–2.00 | | Skin | | | | | | Psoriasis area and severity index (score 0–72) | 5.60 | 4.93 | 4.30 | 1.80–8.40 | | Peripheral joint counts | | | | | | 28 tender joint count | 4.46 | 4.45 | 4.00 | 0.00–8.00 | | 28 swollen joint count | 2.02 | 2.24 | 2.00 | 0.00–4.00 | | 68 tender joint count | 6.06 | 5.97 | 4.50 | 0.50–11.00 | | 66 swollen joint count | 2.80 | 2.99 | 2.00 | 0.00–5.00 | | Patient/physician NRS scores | | | | | | Pain (0–10) | 35.46 | 24.96 | 40.00 | 10.00–55.00 | | Fatigue (0–10) | 32.82 | 24.37 | 35.00 | 10.00–55.00 | | PtGA (0–10) | 4.10 | 3.04 | 4.0 | 1.0–6.5 | | EGA (0–10) | 3.56 | 2.55 | 4.0 | 1.0–6.0 | | GH (0–100) | 36.58 | 21.74 | 4.0 | 0–100 | | Health-related quality of life and function | | | | | | SF36 PCS | 40.47 | 9.08 | 39.87 | 33.43–47.92 | | SF36 MCS | 42.00 | 11.40 | 40.51 | 32.87–51.04 | | DLQI (0–30) | 9.22 | 7.02 | 7.00 | 3.00–16.00 | | HAQ (0–3) | 0.92 | 0.62 | 0.87 | 0.36–1.50 | | Composite activity indices | | | | | | DAS28-CRP | 3.17 | 1.59 | 3.59 | 1.44–4.46 | | DAS28-ESR | 2.73 | 1.48 | 3.13 | 1.11–3.99 | | SDAI | 19.69 | 17.07 | 21.00 | 3.14–30.94 | | CPDAI | 6.52 | 4.49 | 5.00 | 3.00–11.00 | | DAPSA | 20.62 | 17.64 | 22.05 | 3.45–32.40 | | PASDAS | 3.93 | 1.78 | 4.21 | 2.18–5.49 |
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ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; PtGA: disease activity patient’s assessment; EGA: disease activity evaluator’s assessment; GH: global health status; SF36 PCS: physical component summary score of the Medical Outcome Survey Short Form-36; SF36MCS: mental component summary score of the Medical Outcome Survey Short Form-36; DLQI: Dermatology Life Quality Index; HAQ: Health Assessment Questionnaire; DAS28: 28-Disease Activity Score; SDAI: Simplified Disease Activity Index; CPDAI: Composite Psoriatic Disease Activity Index; DAPSA: disease activity in psoriatic arthritis; PASDAS: Psoriatic Arthritis Disease Activity Score.
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