Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 5
Effects of various selective EP receptor agonists on esophageal lesions in rats. Esophagitis was induced by ligation of both the pylorus and forestomach, and animals were killed 3 h later. 17-Phenyl PGE2 (EP1 agonist: 0.3~3 mg/kg), ONO-AE1-259 (EP2 agonist: 0.1~1 mg/kg), ONO-NT-012 (EP3 agonist: 0.3 and 1 mg/kg), and ONO-AE1-329 (EP4 agonist: 1~30 μg/kg) were given i.v. 10 min before the double ligation. The esophageal mucosa was examined 4 h later. Data are presented as the mean ± SE for 4~6 rats. *Significantly different from the control, at (from [16] after modifications).
