Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids

Figure 6

Influence of ONO-AE-829 on the stimulatory effect of PGE₂ on pepsin secretion in rats under urethane anesthesia. An acute fistula stomach was filled with 2 mL of saline through the fistula, and the solution was changed every 15 min. PGE₂ (1 mg/kg) was given i.v. 30 min after the start of the experiment, while ONO-AE-829 (30 mg/kg) was given s.c. 1 h before the administration of PGE₂. Data are presented as the mean ± SE of values determined every 15 min for 4~5 rats. Significant difference at 𝑃<0.05; *from saline; ^#from PGE₂ alone.