Animal Model of Acid-Reflux Esophagitis: Pathogenic Roles of Acid/Pepsin, Prostaglandins, and Amino Acids
Figure 9
Effects of indomethacin and L-NAME on the protective action of L-arginine or glycine against acid-reflux esophagitis in rats. Under ether anesthesia, both the pylorus and forestomach were ligated, and the esophageal mucosa was examined 3 h later. L-arginine (250 mg/kg) or glycine (750 mg/kg) was given i.g. immediately after the ligation. Indomethacin (5 mg/kg) or L-NAME (10 mg/kg) was given s.c. 30 min before the ligation. Data are presented as the for 4~6 rats. *Significantly different from the control, at (from [17] after modifications).
