Inference of SNP-Gene Regulatory Networks by Integrating Gene Expressions and Genetic Perturbations

Algorithm 3

Iterative adaptive lasso in Step 3.

(1)  procedure ITERATIVE ADAPTIVE LASSO(𝑌,𝑋,𝐵,𝐹)⊳Ne(𝐵) denote the number of non-zero elements in 𝐵 and 𝐹

(2)  [𝐵^𝑅,𝐹^𝑅]=𝑅𝑖𝑑𝑔𝑒(𝑌,𝑋,Λ^𝑅₁,𝐹)

(3)  𝛼=1, 𝛽=1

(4)  for  𝑖←1,𝑀_𝑔  do

(5)   [𝐛_𝑖,𝐟_𝑖]=𝐴𝑑𝑎𝑝𝑡𝑖𝑣𝑒𝐿𝑎𝑠𝑠𝑜(𝑌,𝑋,𝜆₁=0.001,𝜆₂=0,𝑖,𝛼,𝛽,𝐛^𝑅_𝑖,𝐟^𝑅_𝑖)

(6)  end for

(7)  while  Ne(𝐵) are decreased by increased 𝛼  do

(8)   while  Ne(𝐵) are decreased  do

(9)    for  𝑖←1,𝑀_𝑔  do

(10)     [𝐛_𝑖, 𝐟_𝑖]=𝐴𝑑𝑎𝑝𝑡𝑖𝑣𝑒𝐿𝑎𝑠𝑠𝑜(𝑌,𝑋,𝜆₁,𝜆₂=0,𝑖,𝛼,𝛽,𝐛_𝑖,𝐟_𝑖)

(11)      end for

(12)   end while

(13)   𝛼=𝛼+1

(14)  end while

(15)  return  𝐵 and 𝐹

(16) end procedure