Plastic Changes in the Spinal Cord in Motor Neuron Disease
Figure 6
GFAP immunostaining within lamina X. Representative high magnification of GFAP immunostained slices from lamina X of lumbar spinal cord (a). The cell number counted within lamina X is equivalent for WT mice treated with either saline (WT Sal) or lithium (WT Li). On the other hand, the cell number is dramatically increased in the lamina X of G93A mice treated with saline (G93A Sal), while it is suppressed in G93A mice treated with lithium (G93A Li) as reported in the histogram (b). In general, GFAP immunostaining shows positive cells on external side of the ependymal layer, while in G93A Sal intense immunostaining extends in the surrounding lamina X. * compared with other groups. Scale bar = 30 μm.
