Plastic Changes in the Spinal Cord in Motor Neuron Disease
Figure 7
βIII-tubulin immunostaining within lamina X. Representative high magnification of βIII-tubulin immunostained slices from lamina X of lumbar spinal cord (a). The cell number counted within lamina X is equivalent for WT mice treated with either saline (WT Sal) or lithium (WT Li). On the other hand, the cell number is dramatically increased in the lamina X of G93A mice treated with lithium (G93A Li), while it is suppressed in G93A mice treated with saline (G93A Sal) as reported in the histogram (b). In general, βIII-tubulin immunostaining shows an opposite pattern compared with GFAP (see Figure 6). Following lithium administration an intense immunostaining is visible throughout the whole lamina X of G93A mice. * compared with other groups. Scale bar = 30 μm.
