Review Article

The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment

Table 5

Chemoattractant GPCRs associated with tumor neovascularization.

ReceptorsTumors

VasculogenesisFPR1Glioma [160]
FPR2Ovarian cancer [123]
CCR2Hepatocellular carcinoma [460]
CCR5Hepatocellular carcinoma [460]
CCR6Hepatocellular carcinoma [461]
CXCR2Pancreatic cancer [462]
CXCR4Breast cancer [320], melanoma [463]

AngiogenesisFPR1Glioma [161, 162, 316]
C5aREpithelial ovarian cancer [17]
CCR1Hepatocellular carcinoma [464], lymphoma [465], multiple myeloma [466]
CCR2Breast cancer [22, 467, 468], esophageal cancer [469], gastric cancer [381], melanoma [470]
CCR4Breast cancer [194]
CCR5Multiple myeloma [466], renal cell carcinoma [326]
CCR10Ovarian cancer [35]
CXCR1Prostate cancer [471], renal cell carcinoma [37]
CXCR2Cervical cancer [472], colorectal cancer [258, 259], glioblastoma [473], lung adenocarcinoma [267, 474, 475], melanoma [418, 476], ovarian cancer [268], pancreatic cancer [269, 477479], prostate cancer [480], renal cell carcinoma [37, 481]
CXCR1/2Glioblastoma [482], melanoma [251, 253], multiple myeloma [483], ovarian cancer [484], pancreatic cancer [485], prostate cancer [254, 451, 486], renal cell carcinoma [37]
CXCR4Breast cancer [487], colorectal cancer [488, 489], gastric cancer [490], glioblastoma [491493], hepatocellular carcinoma [494], ovarian cancer [495], pancreatic cancer [269, 496], prostate cancer [497], squamous cell carcinoma [398]
CXCR6Hepatocellular carcinoma [3], prostate cancer [295]
CXCR7Bladder cancer [498], breast cancer [297], breast and lung cancer [499], colorectal cancer [488], hepatocellular carcinoma [301], prostate cancer [500], renal cell carcinoma [501]
CX3CR1Breast cancer [96], colorectal cancer [149], melanoma [502]