Alterations in Lipid Mediated Signaling and Wnt/β-Catenin Signaling in DMH Induced Colon Cancer on Supplementation of Fish Oil

Figure 1

Effect of different ratios of fish oil and corn oil on ceramide levels in experimentally induced colon cancer. Chromatogram depicts (a) peak of ceramide standard, (b) peak of test sample, (c) band intensity in different groups of initiation phase, and (d) band intensity in different groups of postinitiation phase. (e) represents expression of ceramide in the initiation and postinitiation phase. Lane 1-band intensity of std. ceramide, 2-control, 3-DMH treated, 4-FO+CO(1 : 1)+EDTA, 5-FO+CO(1 : 1)+DMH, 6-FO+CO(2.5 : 1)+EDTA, and 7-FO+CO(2.5 : 1)+DMH. The results are expressed as Mean ± S.D. for 𝑛=8. ^∗∗∗𝑃<0.001 with respect to control, ^###𝑃<0.001 with respect to DMH, ^##𝑃<0.01 with respect to DMH, and ^†††𝑃<0.001 with respect to FO : CO(1 : 1)+DMH.

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