Alterations in Lipid Mediated Signaling and Wnt/β-Catenin Signaling in DMH Induced Colon Cancer on Supplementation of Fish Oil

Table 3

Effect of fish oil and corn oil on expression and nuclear localization of β-catenin in the colon cancer.

Groups	Initiation phase; (% of β-catenin positive cells)			Postinitiation phase; (% of β-catenin positive cells)
	Membranous	Cytoplasmic	Nuclear	Membranous	Cytoplasmic	Nuclear
Control group	5.85 ± 3.95	—	—	8.56 ± 2.35	—	—
DMH treated	12.47 ± 1.29***	18.36 ± 5.34***	16.89 ± 1.56***	45.32 ± 4.22***	19.03 ± 2.94***	15.45 ± 2.34***
FO : CO (1 : 1) + EDTA	6.71 ± 2.54	—	—	10.43 ± 0.88	—	—
FO : CO (1 : 1) + DMH	8.56 ± 1.58^###	6.67 ± 2.69^###	—	20.68 ± 2.36^###	5.96 ± 3.87^###	3.40 ± 0.56^###
FO : CO (2.5 : 1) + EDTA	8.36 ± 3.62	—	—	7.68 ± 1.65	—	—
FO : CO (2.5 : 1) + DMH	11.91 ± 2.56^†	—	—	4.56 ± 1.23^###	—	—

The results are expressed as Mean ± S.D. for n = 8.
^∗∗∗𝑃<0.001 with respect to control, ^###P < 0.001 with respect to DMH, and ^†P < 0.05 with respect to FO : CO (1 : 1) + DMH.