Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure

Table 2

Top three most enriched biological processes of genes differentially expressed in human peripheral blood mononuclear cells when exposed to varying doses of ⁶⁰Co radiation according to the gene ontology enrichment analysis.

Dose	GO ID	Biological process	value (BH)	Gene symbol
0.5	GO:0045935	Positive regulation of nucleobase-containing compound metabolic process	0.0012^a	SS18, SMARC2, EPAS1, LHX1, ZNF148, KLF6, F2R
	GO:0051254	Positive regulation of RNA metabolic process	0.0006^a	TNSF10, MCL1
	GO:2001236	Regulation of extrinsic apoptotic signaling pathway	0.0011^a	TNSF10, MCL1
1	GO:0002376	Immune system process	0.0018	109 genes^b
	GO:0006955	Immune response	0.0213	69 genes^b
	GO:0012501	Programmed cell death	0.03	88 genes^b
2.5	GO:0044092	Negative regulation of molecular function	0.0299	NKX3-1, DUSP6, CDC27, PRDX3, CAST, PSMC2, BAX, AZIN1, PSMA1, PELI1, CD44, HIPK3, SERPINB2, PI3, SENP2, RLIM, THBS1
	GO:0019221	Cytokine-mediated signaling pathway	0.0299	IL1R1, RANBP2, CCL2, NUP54, CD44, IL1A, IFNGR1, KLF6, EIF4G2, JAK3, CXCR3, HLA-DRB5
	GO:0071345	Cellular response to cytokine stimulus	0.0299	RANBP2, IL1R1, RANBP2, CCL2, NUP54, CD44, IL1A, IFNGR1, KLF6, EIF4G2, JAK3, CXCR3, HLA-DRB5
5	GO:0071310	Cellular response to organic substance	0.009	34 genes^b
	GO:0019221	Cytokine-mediated signaling pathway	0.0034	USP18, NUP54, IFNAR1, IL1A, CXCR3, EIF4G2, NUP98, TRADD, SOCS3, NUMBL, RANBP2, PML, PTPRN, CD44, JAK3, HLA-DRB5, CAMK2A
	GO:0070887	Cellular response to cytokine stimulus	0.0162	37 genes^b

The raw value for the GO analysis.
The gene identities are given in the Supplementary Material 1 along with the rest of the GO enrichment analysis results.