Etiopathogenesis and Therapy of Epithelial Ingrowth after Descemet’s Stripping Automated Endothelial Keratoplasty

Table 1

Literature review of epithelial migration into anterior chamber after DSAEK.

Study	Numeber of eye(s)	Description	Diagnosis	Graft failure	Treatment
Culbertson [13]	1	Epithelial downgrowth	Confocal microscopy	No	PK
Koenig and Covert [17]	1	Epithelial ingrowth,interface	Histology	Yes	Repeat DSAEK
Walker et al. [19]	1	Epithelial downgrowth, at the interface	Confocal microscopy, histology	No	PK
Prasher et al. [9]	2	Case  1-epithelial downgrowth, interface	Histology	Yes	Case  1 had PK
		Case  2-epithelial downgrowth, not at the interface			Case  2 had DSAEK
Phillips et al. [14]	1	Conjunctival epithelial downgrowth, over donor endothelium	Histology	Yes	Repeat DSAEK
Gorovoy and Ratanasit [5]	1	Epithelial downgrowth, not at the interface	Histology	Yes	Repeat DSAEK
Saelens et al. [11]	1	Epithelial ingrowth in the flap-graft interface	Histology		Posterior mushroom keratoplasty
Lee et al. [24]	1	Epithelial ingrowth at the interface	Histology	Yes	Repeat DSAEK
Suh et al. [18]	5	Epithelial ingrowth interface-1	AS-OCT-1, spectral domain	None documented	Observation in 4 cases
		Interface retrocorneal-4	Ultrahigh resolution OCT-3, histology-1		Corneoscleral grafting in one case
Bansal et al. [8]	1	Epithelial ingrowth after stromal puncture	Clinical	No	Nil
Ghosh et al. [16]	1	Epithelial ingrowth interface	Histology	Yes	Repeat DSAEK
Wong et al. [34]	1	Interface haze (atypical presentation of epithelial ingrowth interface)	Slit lamp, translucent membrane whitened after argon laser photocoaugulation	Yes	3 DSAEKs; intracameral 5-FU

DSAEK: Descemet stripping automated endothelial keratoplasty; PK: penetrating keratoplasty; AS-OCT: anterior segment optical coherence tomography; OCT: optical coherence tomography.