Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation

Figure 2

Effect of nitric oxide exposure on cell migration and anoikis response. Cells were exposed to DETA NONOate at various concentrations (10 and 25 μM) for 14 days and subjected to migration and anoikis assays. (a) The relative cell migration was determined as described in Material and Methods Section. (b) Viability of the cells after detachment was evaluated in a time-dependent manner. The data are the mean ± S.D. (𝑛=3). ^∗𝑃<0.05 versus the control cells.

(a)

(b)