Prolonged Nitric Oxide Exposure Enhances Anoikis Resistance and Migration through Epithelial-Mesenchymal Transition and Caveolin-1 Upregulation

Figure 6

Nitric oxide mediated caveolin-1 upregulation and epithelial-mesenchymal transition in other lung cancer cells. H292 (a) and H460 (d) lung cancer cells were exposed to DETA NONOate for 14 days and expression levels of Cav-1, vimentin, and snail were determined. The immunoblot signals were quantified by densitometry. Migratory activity of H292 (b) and H460 (c) cells was evaluated as described. Morphology of H292 (c) and H460 (f) cells treated with DETA NONOate for 14 days. The data are the mean ± S.D. (𝑛=3). ^∗𝑃<0.05 versus the nontreated control.

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