Exploring the miRNA-mRNA Regulatory Network in Clear Cell Renal Cell Carcinomas by Next-Generation Sequencing Expression Profiles

Figure 4

Interaction network of upregulated genes and downregulated miRNAs in ccRCC. Post-transcriptional regulation of a gene by an miRNA was assumed to be valid if it is supported by at least three interaction databases. MiRNAs are indicated in blue and mRNAs are indicated in red. Interactions between an miRNA and a 3′UTR of a gene are visualized by arrows. Green arrows visualize interactions that have recently been validated in cell lines; grey arrows indicate that the interaction currently lacks experimental validation.