Murine Aortic Smooth Muscle Cells Acquire, Though Fail to Present Exogenous Protein Antigens on Major Histocompatibility Complex Class II Molecules

Figure 4

SMCs lack key costimulatory molecules. Representative flow cytometry histograms and relative graph showing the effect of IFN-γ (100 ng/mL) on costimulatory/adhesion molecules expression in murine SMCs. Red empty histograms: isotype control; gray filled histograms or white columns: unstimulated SMCs; black empty histograms or black columns: IFN-γ-stimulated SMCs. Results are expressed as mean ± SEM from three separate experiments run in triplicate. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus unstimulated cells.