Serologic Intestinal-Fatty Acid Binding Protein in Necrotizing Enterocolitis Diagnosis: A Meta-Analysis

Table 1

Characteristics of the studies examining the role of I-FABP in NEC diagnosis.

Study	Country	Population ()			Control	Demographic characteristic		Testing time^1	Measure method	Cut-off (ng/mL)	QUADAS
		NEC I	NEC II	NEC III		Birth weight (g)	Gestational age (wk)
Aydemir et al. 2011 [19]	Turkey	22	11	8	31	Cases: 1410 ± 315 g; Controls: 1454 ± 276 g	Cases: 30.2 ± 1.2 wk; Control: 30.4 ± 1.3 wk	At onset and 24 and 72 h point	ELISA	0.76	7
Benkoe et al. 2014 [20]	Austria	5	5	5	14	Cases: 1156 ± 507 g; Controls: 1128 ± 702 g	Cases: 29.0 ± 0.6 wk; Control: 28.6 ± 1.1 wk	At onset, 24 h point	RIA	2.80	6
Edelson et al. 1999 [21]	America	11	12	7	30	Cases: 1251 ± 119 g; Controls: 1277 ± 271 g	Cases: 28.9 ± 1.2 wk; Control: 29.1 ± 0.6 wk	<24 h	ELISA	1.87	8
Guan et al. 2014 [22]	China	15	23	12	41	Cases: 1211 ± 315 g; Controls: 1198 ± 691 g	Cases: 28.1 ± 1.5 wk; Control: 27.9 ± 1.1 wk	At 8, 16, and 24 h	ELISA	2.00	8
Guthmann et al. 2002 [23]	Germany	5	3	6	26	Cases: 1298 ± 572 g; Controls: 1342 ± 180 g	Cases: 29.8 ± 0.2 wk; Control: 30.4 ± 1.7 wk	<24 h	ELISA	2.52	7
Ng et al. 2013 [24]	Hong Kong	0	8	12	40	Cases: 1143 ± 267 g; Controls: 1113 ± 383 g	Cases: 28.4 ± 1.8 wk; Control: 27.8 ± 1.6 wk	At 24 and 72 h	ELISA	7.70	7
Ren et al. 2013 [25]	China	14	23	10	45	Cases: 1220 ± 103 g; Controls: 1290 ± 125 g	Cases: 29.1 ± 0.9 wk; Control: 30.4 ± 1.1 wk	At onset and 8, 24, and 72 h point	ELISA	3.20	5

Testing time: testing time of plasma sample.