Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression

Figure 1

The effects of subchronic arsenic exposure on EPM behavior test. Normal mice and reserpine pretreated mice treated with 10 mg/L arsenic or drinking water alone were analyzed by the elevated plus maze (EPM) test at 4 and 8 weeks. The percentage of time spent (as 100% in 10 minutes) in the open arms (a) and closed arms (b) and the % ratio of time spent in the open/closed arms (c) were evaluated during the 10-minute test period. Each value/error bar is expressed as the mean ± SD of 8 mice. , , and , significant difference compared with normal control group. , , significant difference from the reserpine group (Res).

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(b)

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