Mass Spectrometry in Pharmacokinetic Studies of a Synthetic Compound for Spinal Cord Injury Treatment

Figure 3

The clearance of IG20 was registered by mass spectrometry in rat serum samples after the IG20 injection. In control group (a) no signal for IG20 was observed, but in injected animals a signal of mass at 550.3 (see arrows) corresponding to IG20 glycoside was detected at 3, 6, 12 and 24 h ((b), (c), (d), and (e)). The IG20 clearance was followed by the average of signal values of IG20 peaks in each serum sample by the time shown (f). The solid line represents a linear regression in which a half-life of ~4 h () of intact IG20 was inferred (f).

(a)

(b)

(c)

(d)

(e)

(f)