A Survey on the Computational Approaches to Identify Drug Targets in the Postgenomic Era

Figure 1

A schematic view of identifying drug-target interactions based on drug-induced gene expression profiles. (a) The drug-induced gene expression profiles across cell lines. (b) Define a gene signature for each compound and calculate the MOA similarity between each pair of drugs. (c) Predict targets for novel drugs with the assumption that drugs with similar MOAs are likely to target same proteins.