Review Article
Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis
Table 3
Summary of subgroup analyses in multiple settings for pooled OS.
| Subgroup | Number of studies | Pooled hazard ratio | 95% CI | Heterogeneity ( value; ) | value |
| Detection method | | | | | | IHC | 10 | 2.00 | [1.33, 2.99] | <0.01; 80% | <0.05 | qRT-PCR | 5 | 1.80 | [1.46, 2.22] | 0.53; 0 | <0.05 | Anatomic structure | | | | | | Gastrointestinal tract | 8 | 1.62 | [1.10, 2.40] | <0.01; 72% | <0.05 | Nongastrointestinal tract | 7 | 2.29 | [1.91, 2.74] | <0.01; 71% | <0.05 | Cancer subtype | | | | | | CRC | 4 | 2.08 | [1.52, 2.85] | 0.29; 19% | <0.05 | GC | 3 | 1.21 | [0.54, 2.75] | <0.01; 84% | 0.64 | HCC | 7 | 2.29 | [1.91, 2.74] | <0.01; 71% | <0.05 |
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Subgroup analyses were performed when there were at least two studies in certain subgroup.
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