Review Article

Prognostic Value of MACC1 in Digestive System Neoplasms: A Systematic Review and Meta-Analysis

Table 3

Summary of subgroup analyses in multiple settings for pooled OS.

SubgroupNumber of studies Pooled hazard ratio95% CIHeterogeneity ( value; ) value

Detection method
 IHC102.00[1.33, 2.99]<0.01; 80%<0.05
 qRT-PCR51.80[1.46, 2.22]0.53; 0<0.05
Anatomic structure
 Gastrointestinal tract81.62[1.10, 2.40]<0.01; 72%<0.05
 Nongastrointestinal tract72.29[1.91, 2.74]<0.01; 71%<0.05
Cancer subtype
 CRC42.08[1.52, 2.85]0.29; 19%<0.05
 GC31.21[0.54, 2.75]<0.01; 84%0.64
 HCC72.29[1.91, 2.74]<0.01; 71%<0.05

Subgroup analyses were performed when there were at least two studies in certain subgroup.