Induction of Ankrd1 in Dilated Cardiomyopathy Correlates with the Heart Failure Progression

Figure 5

Antiapoptotic response in end-stage IDCM. Speculatively, ongoing apoptosis and myocyte overstretch in vicious cycle mediate the LV remodeling, whereas myocyte stretch induces Ankrd1 expression and increases adiponectin levels by unknown mechanism that in turn inhibit apoptotic signaling. Arrows indicate process dynamics in NYHA <IV to NYHA IV transition.