A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress

<div>The irreversibility of apoptotic induction is tested by transient treatment with high level of ER stressor. HepG2 cells were treated with high concentration of DTT and washed out after (left panel) 30 min and (right panel) 60 min (a). The autophagy (LC3II, p62) and apoptosis markers (procaspase-3, cleaved PARP) were followed in time by immunoblotting. 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BioMed Research International

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Figure 7

Figure 7: A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress 