Hematopoietic Cancer Cell Lines Can Support Replication of Sabin Poliovirus Type 1

Figure 3

Replication kinetics of Sabin poliovirus type 1 (open circles) and adapted Sabin poliovirus type 1 that was serially passaged on Vero, K562, KG1, and U937 cells (black squares). Cells were infected with Sabin poliovirus type 1 from passage 0 or passage 5 and the titer in the supernatant was determined at days 1, 2, 4, and 7 after infection by endpoint dilution. The total amount of plaque forming units in these samples was determined and the mean ± SD from 3 independent experiments is shown.