Hematopoietic Cancer Cell Lines Can Support Replication of Sabin Poliovirus Type 1

Figure 4

Infection of Vero, K562, KG1, or U937 at an MOI of 0.01 with passaged Sabin poliovirus type 1 on the various cell lines results in a high virus titer in the supernatant after 4 or 7 days. After infection, both cells (black) and supernatants (grey) were harvested at day 4 and day 7, and the virus titer was determined in these samples. The total amount of plaque forming units in these samples was determined and the mean ± SD from 3 independent experiments is shown.