DNaseI Protects against Paraquat-Induced Acute Lung Injury and Pulmonary Fibrosis Mediated by Mitochondrial DNA

Figure 3

PQ-primed mtDNA stimulates alveolar epithelial (A549) cell production of TGF-β1. (a) PQ-primed mtDNA did not stimulate fibroblast (HFL1) proliferation. (b) PQ-primed mtDNA increased A549 cell TGF-β1 expression but had no effect on epithelial-mesenchymal transition marker expression (c) nor on downregulating epithelial marker expression (d).

(a)

(b)

(c)

(d)